Drug resistance of pathogens causing nosocomial infection in orthopedics from 2012 to 2017: a 6-year retrospective study

Abstract Background Hospital-acquired infections (HAIs) are an emerging global problem that increases in-hospital mortality, length of stay, and cost. We performed a 6-year retrospective study to provide valuable insight into appropriate antibiotic use in HAI cases. also aimed understand how hospitals could reduce pathogen drug resistance population overuses antibiotics. Methods All data (2012–2017) were obtained from the hospital information warehouse clinical microbiology laboratory. Results isolated 1392 strains patients admitted orthopedics department during 2012–2017. Escherichia coli (14.7%, 204/1392), Enterobacter cloacae (13.9%, 193/1392), Staphylococcus aureus (11.3%, 157/1392) most common pathogens causing nosocomial infections. The dominant Gram-negative bacterium was E. , with high ampicillin, levofloxacin, cotrimoxazole, gentamicin, ciprofloxacin, order. least resistant amikacin, cefoperazone-sulbactam. Gram-positive S. highly penicillin but not fluoroquinolones cotrimoxazole. Analysis risk factors related multidrug-resistant bacteria showed open fractures (Gustillo III B IIIC) significantly more susceptible methicillin-resistant ( p < 0.05). Additionally, extended-spectrum β-lactamase-producing occurred often degenerative diseases Elderly tended be bacterial infections, this outcome statistically significant. Conclusions Antimicrobial is serious orthopedics. To effectively control antimicrobial among pathogens, we advocate extensive dynamic monitoring MDR bacteria, coupled careful